Stroke damage can be reduced with estrogen
Estrogen can minimize the risk of stroke damage by inactivating a tumor-suppressing protein, P53, which is known to inhibit many cancer forms according to researchers at the Medical College of Georgia.
It was remarked by Limor Raz, a fourth-year Ph.D. student in the MCG School of Graduate Studies, that the research highlighted the fact that estrogen is potent to suppress P53 after stroke to inhibit damage.
From Sciencedaily.com:
Ms. Raz found that estrogen can chemically alter p53 and attenuate the cascade, thus leading to reduced stroke damage.
She has been working with Dr. Darrell Brann, chief of developmental neurobiology and associate director of the MCG Institute of Molecular Medicine and Genetics, and will present her findings today in Colorado at the American Physiological Society conference focusing on the cardiovascular effects of sex steroids and gender.
Global cerebral ischemia, the most common type of ischemic stroke, in which blood flow to the brain is disrupted, was induced, damaging primarily the hippocampal CA1 region of the brain. In this study, a group of female rats were treated with estrogen versus placebo for seven days and estrogen’s effect on p53 signaling was examined.
P53 is the protein in the mitochondria that is hailed as guardian of the genome because of the fact that it regulates the cell cycle besides preventing genome mutation.
